Research Roundup


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Debbie Rigby takes a look at the latest in research news

Statin associated lower cancer risk and related mortality in patients with heart failure

Patients with heart failure (HF) have an increased risk of incident cancer. In this study, statin use was associated with a significantly lower risk of incident cancer and cancer-related mortality in HF. This association with risk of cancer was duration dependent. Ten-year cancer-related mortality was 3.8% among statin users and 5.2% among nonusers.

European Heart Journal, ehab325.

 

Prunes improve cholesterol and reduce inflammation

Dried plums contain bioactive components that have demonstrated antioxidant and anti-inflammatory effects. This small study of 48 healthy postmenopausal women suggests that daily consumption of 50–100 g dried plum (about 5-6 prunes) for 6 months improves CVD risk factors. Eating prunes daily also promoted higher antioxidant capacity and lowered levels of the inflammatory cytokines IL-6 and TNF-a associated with CVD risk.

Journal of Medicinal Food, published online 11 May 2021.

 

Central sensitisation in chronic pain conditions

Central sensitisation, defined as an amplification of neural signalling within the CNS that elicits pain hypersensitivity, is a feature of many pain conditions, including fibromyalgia, osteoarthritis, rheumatoid arthritis, Ehlers-Danlos syndrome, upper extremity tendinopathies, headache, and spinal pain. Antidepressants are effective in different chronic musculoskeletal pain conditions associated with central sensitisation.

Lancet Rheumatology 2021;3(5):E383-92.

 

Acne vulgaris: management

This NICE guideline covers management of acne vulgaris in primary and specialist care. It includes advice on topical and oral treatments (including antibiotics and retinoids), treatment using physical modalities, and the impact of acne vulgaris on mental health and wellbeing.

NICE guideline, published 25 June 2021.

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