Research Roundup

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Association between prediabetes and risk of all cause mortality and cardiovascular disease

A meta-analysis of 129 studies involving over 10 million patients shows that prediabetes is associated with an increased risk of all-cause mortality and cardiovascular disease in the general population and in patients with atherosclerotic cardiovascular disease. The authors conclude that screening and appropriate management of prediabetes might contribute to primary and secondary prevention of cardiovascular disease.

BMJ 2020;370:m2297.


Regimens of vitamin D supplementation for women during pregnancy

In the Cochrane review of 30 trials involving over 7000 pregnant women, vitamin D supplementation made little or no difference to the risk of pre‐eclampsia, preterm birth and low birthweight. Vitamin D supplementation with 600IU/day may reduce the risk of gestational diabetes compared to less than 600IU/day.

Cochrane Database of Systematic Reviews 2019, Issue 10.


Effect of low‐dose aspirin on health outcomes

An umbrella review of systematic reviews and meta‐analyses explored the range of outcomes associated with low-dose aspirin. Observational data showed strong evidence for lower risk of cardiovascular disease in people without CVD and in general population; and a higher risk of major gastrointestinal and intracranial bleeding in people without CVD. This review showed little evidence that low-dose aspirin prevents overall and specific CVD events in diabetes.

Br J Clin Pharmacol 2020;86:1465–1475.


Anticholinergic burden and delirium

Anticholinergic drug burden is associated with delirium. Delirium is very common among older patients and is associated with poor outcomes, such as functional and cognitive decline and increased mortality. A systematic review of the literature found an association between high anticholinergic burden and delirium during 3-month and 1-year follow-up.

Journal of American Medical Directors Association, published 20 July 2020.

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