Vitamins in families at high risk of ASD

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A small observational study has suggested that prenatal vitamins could reduce autism risk in some families

Authors Rebecca J Schmidt, Ana-Maria Iosif and Elizabeth Guerrero Angel set out to investigate whether maternal use of prenatal vitamins could be associated with a decreased risk for autism recurrence in siblings of children diagnosed as being on the autism spectrum.

While maternal use of folic acid supplements has been inconsistently associated with reduced risk for ASD in a children, no study to date has examined this association in the context of ASD recurrence in high-risk families, they write in JAMA.

“This prospective cohort study analyzed data from a sample of children (n = 332) and their mothers (n = 305) enrolled in the MARBLES (Markers of Autism Risk in Babies: Learning Early Signs) study,” they write.

“Participants in the MARBLES study were recruited at the MIND Institute of the University of California, Davis and were primarily from families receiving services for children with ASD in the California Department of Developmental Services.

“In this sample, the younger siblings at high risk for ASD were born between December 1, 2006, and June 30, 2015, and completed a final clinical assessment within 6 months of their third birthday.

“Prenatal vitamin use during pregnancy was reported by mothers during telephone interviews. Data analysis for this study was conducted from January 1, 2017, to December 3, 2018.”

After exclusions, the final sample included 241 younger siblings, of which 140 (58.1%) were male and 101 (41.9%) female.

“Most mothers (231 [95.9%]) reported taking prenatal vitamins during pregnancy, but only 87 mothers (36.1%) met the recommendations to take prenatal vitamins in the 6 months before pregnancy,” the authors write.

“The prevalence of ASD was 14.1% (18) in children whose mothers took prenatal vitamins in the first month of pregnancy compared with 32.7% (37) in children whose mothers did not take prenatal vitamins during that time.

“Children whose mothers reported taking prenatal vitamins during the first month of pregnancy were less likely to receive an ASD diagnosis (adjusted relative risk [RR], 0.50; 95% CI, 0.30-0.81) but not a non-TD 36-month outcome (adjusted RR, 1.14; 95% CI, 0.75-1.75) compared with children whose mothers reported not taking prenatal vitamins.

“Children in the former maternal prenatal vitamin group also had statistically significantly lower autism symptom severity (adjusted estimated difference, –0.60; 95% CI, –0.97 to –0.23) and higher cognitive scores (adjusted estimated difference, 7.1; 95% CI, 1.2-13.1).”

The authors point out that the study was observational, and that there may have been differences between the two groups which were not accounted for during the analysis, despite the authors having accounted for a number of factors.

“Maternal prenatal vitamin intake during the first month of pregnancy may reduce ASD recurrence in siblings of children with ASD in high-risk families,” they conclude.

“Additional research is needed to confirm these results; to investigate dose thresholds, contributing nutrients, and biologic mechanisms of prenatal vitamins; and to inform public health recommendations for ASD prevention in affected families.”

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